Phages bearing affinity peptides to severe acute respiratory syndromes-associated coronavirus differentiate this virus from other viruses
Identifieur interne : 001884 ( Main/Exploration ); précédent : 001883; suivant : 001885Phages bearing affinity peptides to severe acute respiratory syndromes-associated coronavirus differentiate this virus from other viruses
Auteurs : Chao Wang [République populaire de Chine] ; Xuejiao Sun [République populaire de Chine] ; Siqingaowa Suo [République populaire de Chine] ; Yudong Ren [République populaire de Chine] ; Xunliang Li [République populaire de Chine] ; Georg Herrler [Allemagne] ; Volker Thiel [Suisse] ; Xiaofeng Ren [République populaire de Chine]Source :
- Journal of Clinical Virology [ 1386-6532 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Bactériophages (génétique), Bactériophages (métabolisme), Banque de peptides, Escherichia coli (génétique), Escherichia coli (métabolisme), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (métabolisme), Humains, Ligands, Peptides (génétique), Souris, Suidae (génétique), Suidae (métabolisme), Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (virologie), Séquence d'acides aminés, Techniques d'exposition à la surface cellulaire (), Tests diagnostiques courants (), Virus du SRAS (génétique), Virus du SRAS (métabolisme).
- MESH :
- diagnostic : Syndrome respiratoire aigu sévère.
- génétique : Bactériophages, Escherichia coli, Glycoprotéine de spicule des coronavirus, Peptides, Suidae, Virus du SRAS.
- métabolisme : Bactériophages, Escherichia coli, Glycoprotéine de spicule des coronavirus, Suidae, Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Banque de peptides, Humains, Ligands, Souris, Séquence d'acides aminés, Techniques d'exposition à la surface cellulaire, Tests diagnostiques courants.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Bacteriophages (genetics), Bacteriophages (metabolism), Cell Surface Display Techniques (methods), Diagnostic Tests, Routine (methods), Escherichia coli (genetics), Escherichia coli (metabolism), Humans, Ligands, Mice, Peptide Library, Peptides (genetics), SARS Virus (genetics), SARS Virus (metabolism), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (metabolism), Swine (genetics), Swine (metabolism).
- MESH :
- chemical , genetics : Peptides, Spike Glycoprotein, Coronavirus.
- chemical , metabolism : Spike Glycoprotein, Coronavirus.
- chemical : Ligands, Peptide Library.
- diagnosis : Severe Acute Respiratory Syndrome.
- genetics : Bacteriophages, Escherichia coli, SARS Virus, Swine.
- metabolism : Bacteriophages, Escherichia coli, SARS Virus, Swine.
- methods : Cell Surface Display Techniques, Diagnostic Tests, Routine.
- virology : Severe Acute Respiratory Syndrome.
- Amino Acid Sequence, Animals, Humans, Mice.
Abstract
Transmission of SARS-associated coronavirus (SARS-CoV) is now well controlled, nevertheless, it is important to develop effective methods to identify this virus from other pathogens.
The purpose of this study was to identify potential ligands and develop a novel diagnostic test to SARS-CoV using phage display technology.
The SARS-CoV spike 1 (S1) protein containing the receptor binding region (RBD) was used as an immobilized target followed by incubation with a 12-mer phage display random peptide library. After four rounds of biopanning, 10 monoclonal phages with specific binding activity to the S1-RBD protein were obtained and subjected to binding and diagnostic assays.
DNA sequencing showed that two phage displayed peptides HHKTWHPPVMHL (phage-H) and SQWHPRSASYPM (phage-S) that were specific ligands to the S1 protein. Moreover, the selected phage-H and phage-S were capable of differentiating SARS-CoV from other coronaviruses in indirect enzyme-linked immunosorbent assays.
The peptides identified in this study are useful reagents for detection of SARS-CoV.
Url:
DOI: 10.1016/j.jcv.2013.04.002
PubMed: 23664850
PubMed Central: 7108448
Affiliations:
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Le document en format XML
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sortKey="Ren, Yudong" sort="Ren, Yudong" uniqKey="Ren Y" first="Yudong" last="Ren">Yudong Ren</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xunliang" sort="Li, Xunliang" uniqKey="Li X" first="Xunliang" last="Li">Xunliang Li</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Preventive Veterinary Medicine, 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Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen CH-9007</wicri:regionArea><wicri:noRegion>St Gallen CH-9007</wicri:noRegion></affiliation></author><author><name sortKey="Ren, Xiaofeng" sort="Ren, Xiaofeng" uniqKey="Ren X" first="Xiaofeng" last="Ren">Xiaofeng Ren</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23664850</idno><idno type="pmc">7108448</idno><idno 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Medicine, Northeast Agricultural University, Harbin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Xuejiao" sort="Sun, Xuejiao" uniqKey="Sun X" first="Xuejiao" last="Sun">Xuejiao Sun</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Suo, Siqingaowa" sort="Suo, Siqingaowa" uniqKey="Suo S" first="Siqingaowa" last="Suo">Siqingaowa Suo</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Ren, Yudong" sort="Ren, Yudong" uniqKey="Ren Y" first="Yudong" last="Ren">Yudong Ren</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xunliang" sort="Li, Xunliang" uniqKey="Li X" first="Xunliang" last="Li">Xunliang Li</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author><author><name sortKey="Herrler, Georg" sort="Herrler, Georg" uniqKey="Herrler G" first="Georg" last="Herrler">Georg Herrler</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Institute for Virology, University of Veterinary Medicine Hannover, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Virology, University of Veterinary Medicine Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen CH-9007, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen CH-9007</wicri:regionArea><wicri:noRegion>St Gallen CH-9007</wicri:noRegion></affiliation></author><author><name sortKey="Ren, Xiaofeng" sort="Ren, Xiaofeng" uniqKey="Ren X" first="Xiaofeng" last="Ren">Xiaofeng Ren</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin</wicri:regionArea><wicri:noRegion>Harbin</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Clinical Virology</title><idno type="ISSN">1386-6532</idno><idno type="eISSN">1873-5967</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Bacteriophages (genetics)</term><term>Bacteriophages (metabolism)</term><term>Cell Surface Display Techniques (methods)</term><term>Diagnostic Tests, Routine (methods)</term><term>Escherichia coli (genetics)</term><term>Escherichia coli (metabolism)</term><term>Humans</term><term>Ligands</term><term>Mice</term><term>Peptide Library</term><term>Peptides (genetics)</term><term>SARS Virus (genetics)</term><term>SARS Virus (metabolism)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (metabolism)</term><term>Swine (genetics)</term><term>Swine (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Bactériophages (génétique)</term><term>Bactériophages (métabolisme)</term><term>Banque de peptides</term><term>Escherichia coli (génétique)</term><term>Escherichia coli (métabolisme)</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (métabolisme)</term><term>Humains</term><term>Ligands</term><term>Peptides (génétique)</term><term>Souris</term><term>Suidae (génétique)</term><term>Suidae (métabolisme)</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Séquence d'acides aminés</term><term>Techniques d'exposition à la surface cellulaire ()</term><term>Tests diagnostiques courants ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peptides</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Ligands</term><term>Peptide Library</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Bacteriophages</term><term>Escherichia coli</term><term>SARS Virus</term><term>Swine</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Bactériophages</term><term>Escherichia coli</term><term>Glycoprotéine de spicule des coronavirus</term><term>Peptides</term><term>Suidae</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bacteriophages</term><term>Escherichia coli</term><term>SARS Virus</term><term>Swine</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cell Surface Display Techniques</term><term>Diagnostic Tests, Routine</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Bactériophages</term><term>Escherichia coli</term><term>Glycoprotéine de spicule des coronavirus</term><term>Suidae</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Humans</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Banque de peptides</term><term>Humains</term><term>Ligands</term><term>Souris</term><term>Séquence d'acides aminés</term><term>Techniques d'exposition à la surface cellulaire</term><term>Tests diagnostiques courants</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Transmission of SARS-associated coronavirus (SARS-CoV) is now well controlled, nevertheless, it is important to develop effective methods to identify this virus from other pathogens.</p></sec><sec><title>Objectives</title><p>The purpose of this study was to identify potential ligands and develop a novel diagnostic test to SARS-CoV using phage display technology.</p></sec><sec><title>Study design</title><p>The SARS-CoV spike 1 (S1) protein containing the receptor binding region (RBD) was used as an immobilized target followed by incubation with a 12-mer phage display random peptide library. After four rounds of biopanning, 10 monoclonal phages with specific binding activity to the S1-RBD protein were obtained and subjected to binding and diagnostic assays.</p></sec><sec><title>Results</title><p>DNA sequencing showed that two phage displayed peptides HHKTWHPPVMHL (phage-H) and SQWHPRSASYPM (phage-S) that were specific ligands to the S1 protein. Moreover, the selected phage-H and phage-S were capable of differentiating SARS-CoV from other coronaviruses in indirect enzyme-linked immunosorbent assays.</p></sec><sec><title>Conclusion</title><p>The peptides identified in this study are useful reagents for detection of SARS-CoV.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name></author><author><name sortKey="Sola, I" uniqKey="Sola I">I. Sola</name></author><author><name sortKey="Almazan, F" uniqKey="Almazan F">F. 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Chan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>République populaire de Chine</li><li>Suisse</li></country><region><li>Basse-Saxe</li></region><settlement><li>Hanovre</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Chao" sort="Wang, Chao" uniqKey="Wang C" first="Chao" last="Wang">Chao Wang</name></noRegion><name sortKey="Li, Xunliang" sort="Li, Xunliang" uniqKey="Li X" first="Xunliang" last="Li">Xunliang Li</name><name sortKey="Ren, Xiaofeng" sort="Ren, Xiaofeng" uniqKey="Ren X" first="Xiaofeng" last="Ren">Xiaofeng Ren</name><name sortKey="Ren, Yudong" sort="Ren, Yudong" uniqKey="Ren Y" first="Yudong" last="Ren">Yudong Ren</name><name sortKey="Sun, Xuejiao" sort="Sun, Xuejiao" uniqKey="Sun X" first="Xuejiao" last="Sun">Xuejiao Sun</name><name sortKey="Suo, Siqingaowa" sort="Suo, Siqingaowa" uniqKey="Suo S" first="Siqingaowa" last="Suo">Siqingaowa Suo</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Herrler, Georg" sort="Herrler, Georg" uniqKey="Herrler G" first="Georg" last="Herrler">Georg Herrler</name></region></country><country name="Suisse"><noRegion><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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